Herguijuela de la Sierra is a village and municipality in the province of Salamanca, western Spain, part of the autonomous community of Castilla y León.

It is located 86 kilometres (53 mi) from the provincial capital city of Salamanca and has a population of 299 people.

It is known, besides for its and other towns in the area's quaint old village air, for having a several-hundred-year-old beech tree nearby, one of two in all of western-central Spain.

The municipality covers an area of 32 square kilometres (12 sq mi).

It lies 800 metres (2,600 ft) above sea level and the postal code is 37619.