He attended the grammar school at the Ichthus College in his hometown, Enschede.

Selderhuis was minister of the Christian Reformed Church in Hengelo from 1987 until 1992.

The following five years he was minister of the Christian Reformed Church in Zwolle.

[4] He also served as the academic curator of the John Lasco Library (Emden, Germany) from 2010 - 2017 and is president of the International Calvin Congress.

[4] [5] He is also director of Refo500, the international platform for knowledge, expertise, ideas, products and events, specializing in the 500 year legacy of the Reformation.