From 2003 to 2008, he ascended to the roles of President for Latin America and General Manager for the United Kingdom within Fox International Channels.

[6] Under his leadership the company reached $3 Billion in annual revenue, growing from $100 million in 2002, by the addition of channels, premium offerings and original productions.

[7] Following his tenure as CEO of Fox International Channels in 2016,[8] he founded Wondery, a podcast network[9][10] that produced shows such as "Dirty John," "Dr. Death," and "Business Wars".

[13] Lopez is credited as an executive producer on TV Series “Doctor Death,” “We Crashed”, and “The Shrink Next Door” along with a number of Wondery original podcasts.

[15][16] In 2019, Lopez raised $10 million in a Series B round led by Waverly Capital which funded international expansion, new programming development, and technology investments.

[23] In 2024, Lopez launched management consulting firm Owl & Co, a company that helps media and entertainment businesses.

[26][27] In September 2023, the Brooklyn Federal Court overturned Lopez's conviction and granted an acquittal, citing a decision by the Supreme Court of the United States to overturn the wire fraud conviction of Joseph Percoco, an aide to former New York Governor Andrew Cuomo, in May that year.