It was released on July 11, 2000, through Def Jam Recordings, as a sequel to 1996 The Nutty Professor Soundtrack, and mainly composed of R&B and hip hop music.

Production was handled by Tim & Bob, Erick Sermon, Brian McKnight, Carvin & Ivan, Christopher "Deep" Henderson, Janet Jackson, Jimmy Jam and Terry Lewis, JoJo Brim, Montell Jordan, P. Killer Trackz, P. King "The Specialist", Redhead Kingpin, R. Kelly, Rodney Jerkins, Sisqó, Teflon and Timbaland, with Brian Grazer, Gary Jones, Happy Walters, Harry Garfield, Kevin Liles and Lyor Cohen serving as executive producers.

It features contributions from Amil, Brian McKnight, Case, DMX, Dyme, Eminem, Eve, Foxy Brown, Janet Jackson, Jay-Z, Jazz, Kandice Love, Memphis Bleek, Method Man, Montell Jordan, Musiq Soulchild, Redman, R. Kelly, Shorty 101 and Sisqó.

Its lead single, "Doesn't Really Matter" topped the Billboard Hot 100 and later appeared in Janet Jackson's seventh studio album All for You (2001).

The album's final single, "Missing You", peaked at number 4 on US Hot 100 and received a Grammy Award for Best Male R&B Vocal Performance nomination, but was replaced in UK/European editions of the compilation with Jayo Felony's "Hotta Than Fish Grease".