Hidde Lolke Ploegh (born 7 January 1953) is an immunologist at Boston Children's Hospital, known for his contributions in understanding antigen processing and the evasion of the immune system by viruses.

Earlier in his career, Ploegh's research focused on the ability of MHC molecules, such as MHC-II, to interact with antigen peptides inside a cell.

[7] More recently, the Ploegh lab at the Whitehead Institute has been using a technique called “sortagging” to look at the pathways through which viruses are able to avoid detection by the immune system.

This makes them ideal for the delivery of drugs through the body as they cannot mutate as a mature cell.

Ploegh and his colleagues have been able to use sortase to cut erythrocyte surface proteins, allowing the binding of biotin and its circulation throughout the body.