The Galvins became one of the first families to be studied by the National Institute of Mental Health, with their DNA samples and experiences forming the cornerstone of research for the disease in the mid-1900s.

[16][17] Kirkus Reviews praised its "astounding depth and empathy" and Kolker's account of schizophrenia's history and the complicated atmosphere and relationships among members of the Galvin family.

[18] In a review for The New York Times, Sam Dolnick wrote, "Kolker tells their story with great compassion" and that the author "is a restrained and unshowy writer who is able to effectively set a mood".

[19] Similarly, in her review for The Washington Post, Karen Iris Tucker described Kolker's retelling of the Galvin family as, "deeply compassionate and chilling," further noting that, "the book gives much space to how difficult the disease has been to diagnose and treat.

"[20] Publishers Weekly called the book a "haunting and memorable" account of multi-generational mental illness and praised Kolker's "taut and often heartbreaking narrative.