In the 1930s she changed her focus to Pan-Asian cooperation and at the end of the decade was appointed to the Ministry of Greater East Asia to work on educational reforms.

[1][3] When she graduated, she became the secretary general of alumni association and then with the encouragement of Hirooka went to the United States to further her education[1] at Teachers College, Columbia University and the Chicago Normal School.

[10] In 1913, through her involvement with the alumni association, Inoue proposed that the graduates hold fundraisers to support a day care system modeled on those she had seen in the United States.

The association held music performances and sold items at a bazaar to pay for the operation of the first day care center in Japan, which opened that year in the Sugamo neighborhood of Tokyo.

[4] She was by that time, head of the home economics department, and traveled to the conference with her secretary, Dr. Marian Irwin, graduate of Bryn Mawr College.

[14] She believed that if Japan agreed with disarmament policies that would make Japanese immigration more attractive in the United States and lessen the overcrowding at home.

[4] Her lectures of the time showed she had not completely abandoned internationalism, as she argued that rationing foreign edibles which had become staples of the culture would be problematic.

[23] Ostensibly, her removal was based on an affiliation with the Imperial Rule Assistance Association because in 1941 she was appointed as the vice president of the Dai Nippon Seishonen-dan,[24] (Greater Japan Youth and Child Group).

[25] Inoue's defense of her actions was that she had opposed both her appointment to the Youth and Child Group and its affiliation with the Imperial Rule Assistance Association,[24] but she became one of the few women purged in the period of occupation.