To avoid it, Hideyoshi exiled his nephew and heir Hidetsugu to Mount Kōya and then ordered him to commit suicide in August 1595.

Hidetsugu's family members who did not follow his example were then murdered in Kyoto, including 31 women and several children[1] and also Mogami Yoshiaki's daughter.

Hideyoshi refused to spare the life of Yoshiaki's daughter, who had only just arrived in Kyoto to become Hidetsugu's concubine and had not yet even met her future husband.

Hideyori's arranged marriage to Senhime, the seven-year-old granddaughter of Ieyasu, was designed to mitigate Toyotomi clan dissension and plotting.

[3] Fourteen years later, Hideyori was now a young daimyō living in Osaka Castle, son and rightful heir to Toyotomi Hideyoshi.

In April 1615, Ieyasu received word that Toyotomi Hideyori was gathering even more troops than in the previous November, and that he was trying to stop the filling of the moat of Osaka Castle.

Hideyori and his mother committed seppuku, and the final major uprising against Tokugawa rule for another 250 or so years was put to an end.

According to James Murdoch's A History of Japan During The Century of Early Foreign Discourse,[4] based heavily upon the works of many Japanese sources (the Nihon Shoki, Miyoshi-Ki, and many more) as well as heavily based on the writings of the Jesuits, their annual letters, the letters of William Adams and the diaries of Adams' Dutch comrades, the events of Hideyori's death and the final fall of Osaka Castle were as such – Sanada Yukimura had been tactician of the climactic battle outside the gates of Osaka.

When the confusion was to be at its height, Hideyori would have marched out of Osaka castle with his home troops and would in theory be the final blow to the Tokugawas.

The plan of creating Tokugawa confusion worked and according to the Jesuits, Ieyasu himself, serving as the ultimate reinforcement to the center force, had told his men to kill him if victory seemed for nigh.

According to the Nihon Senshi: "Hideyori, when he received intelligence of the defeat of his rōnin, said, "Death is what I have been ready to meet for long", and was about to sally from the castle in order to fight his very last battle when he was stopped by Hayami, one of his seven captains, who urged that a commander-in-chief should not expose his person among the promiscuous dead.

This Hayami, one of his seven captains, eventually lead Hideyori, his wife, the daughter of the shōgun and granddaughter of Ieyasu, and his mother, Yodogimi to a fire proof keep in the castle.

Adames went againe to the Cort [at Yedo] to procure our dispatch, and found all the Council busied about matters of justice of life and death; and amongst the rest, one man was brought in question about Fidaia Samme [Hideyori], as being in the castle with him to the last hour.

"May 5th, 1616 The son of Tuan Dono of Langasaque [ Nagasaki ] [i.e the brother of the Japanese Jesuit killed at the storming of Osaka], departed to sea with 13 barkes laden with soldiers to take the island Taccasange, called per them soe, but by us Isla Fermosa.