It runs one-way for around 0.81 miles (1.30 km), from Commercial Street in the southeast to Forest Avenue in the northwest.

[1] Running one-way for its entire length, High Street begins at Commercial Street, directly opposite Becky's Diner,[2] on a steep incline.

The slope is shared with Park Street, on the opposite side of the Irving gas station separating the two.

[3] From there, a steep decline begins to its intersection with Forest Avenue.

The street passes through the eastern edge of Deering Oaks Park for its final 700 feet (210 m) or so, before it intersects with Forest Avenue at the beginning of U.S. Route 302.