The station is located south of the High Bridge off Depot Place and Exterior Drive, and is accessible from Sedgwick Avenue by way of a viaduct that carries Depot Place over the Major Deegan Expressway, the Hudson Line, and Exterior Drive.

With the opening of the line, most passenger trains were rerouted into the new Grand Central Depot via that line along the northeast bank of the Harlem River and the New York and Harlem Rail Road, which was also part of the New York Central system.

[3] The NYCRR's long-distance passenger trains, including the Wolverine, 20th Century Limited, and Lake Shore Limited, picked up their dining cars at High Bridge after leaving Grand Central Terminal, but High Bridge was not an official stop for those trains.

High Bridge also had a tractor trailer/freight yard where trucks would load their trailers on to flat cars for "piggyback" service.

A scene in the movie Funny Girl shows Barbra Streisand riding one of the NYCRR tugs.