It travels through Muskoka District and Parry Sound District, travelling through the communities of Humphrey, Rosseau, Bent River (off-route but nearby), Ullswater, Raymond and Utterson.

Rosseau is the largest community located directly on the route.

These two routes met southeast of Raymond, at what is now the junction with Muskoka District Road 35.

[7] In the summer of 2012, Highway 69 was decommissioned in the area; the old route is now known as Rankin Lake Road north of the shared segment and Lake Joseph Road south of it.

[8] The following table lists the major junctions along Highway 141, as noted by the Ministry of Transportation of Ontario.