This is a list of secondary highways in Nipissing District, many of which serve as logging roads or provide access to Algonquin Park and sparsely populated areas in the Nipissing District of northeastern Ontario.

The highway is a 20.1-kilometre (12.5 mi) north–south route in Nipissing District which follows the historic Madawaska Colonization Road.

It provides access to Algonquin Provincial Park from the north at Kioshkakwi Lake.

It was assumed as a provincial route on July 28, 1961, by which time it was paved north of Eau Claire.

It provides access to the Otto Holden Generating Station on the Ottawa River from a junction with Highway 533 located just north of Mattawa, a distance of 3.7 kilometres (2.3 mi).