Highway 68 was a 116.8 km (72.6 mi) route that crossed the eastern side of Manitoulin Island in a north–south orientation between South Baymouth and Little Current.

[2] Communities along the route include South Baymouth, Squirrel Town, Manitowaning, Sheguiandah, Little Current, McGregor Bay, Whitefish Falls, West River and Espanola.

[1] The history of Highway 68 dates to 1929, when the Department of Northern Development (DND) constructed a 56 km (35 mi) gravel road between McKerrow and Goat Island.

On April 1, 1937, the DND merged into the Department of Highways (DHO), and the latter began to assume and number trunk roadways in central and northern Ontario.

[4] During World War II, the rail bridge over the North Channel was abandoned, and subsequently redecked for highway use in 1945.

[8] The two discontinuous sections of Highway 6 are linked only by a privately operated ferry, MS Chi-Cheemaun, which crosses Georgian Bay daily from May to October between South Baymouth and Tobermory.