M12 was a Ukrainian international highway (M-highway) connecting Lviv Oblast to Central Ukraine, where after crossing the Dnieper it continued further as the M04.

The highway is also part of the Gdańsk - Odesa Transportation corridor on the segment from Ternopil to Uman.

For the entire route from Stryi to Znamianka the M12 is part of the E50, however in Kropyvnytskyi it is also joined by the E584 that travels from Moldova to Poltava.

[2] Main route and connections to/intersections with other highways in Ukraine.

The highway passes the following cities going around them, however it has spurred away access routes towards them.