Highways in Hiding is a science fiction novel by American writer George O. Smith.

This is set against the plot of a secret society that is harboring people that are infected with a spaceborne illness called Mekstrom's Disease.

To hide themselves from the public at large they have devised a hidden highway program that leads the infected to "Mekstrom safehouses" of sorts.

J. Francis McComas found Highways in Hiding to be "a tasty enough dish for those on a diet of pure melodrama," concluding that "Our hero's adventures go on a bit too long, but over all, his exploits are entertaining.

"[1] Galaxy reviewer Floyd C. Gale praised the novel for its "suspense [and] crackling, hard-boiled dialogue.