She served as a Senator for Buenos Aires Province, and as the First Lady during the presidency of her husband, Eduardo Duhalde.

She assisted her husband in his political career and took on several public positions in family and women's policy.

In 1997 Duhalde was elected a National Deputy for Buenos Aires Province, serving again between 2003 and 2005.

A member of the Justicialist Party (PJ), Duhalde has nevertheless opposed the government of fellow Peronists Néstor Kirchner.

However the official PJ candidate in Buenos Aires Province district for the 2005 senatorial elections, Hilda Duhalde came second to Cristina Fernández de Kirchner, who was to become President of Argentina two years later.