The 167-bed facility was founded in 1918 in downtown and is one of two hospitals in Hillsboro, Washington County's most populous city.

[2][3] At six stories tall, the main building was tied for the tallest in the city with the Hillsboro Civic Center as of 2006.

Six years later, another expansion was completed, with additional surgery areas, another delivery room, and a laboratory.

[6] In 1978, a fourth floor with 44 beds was added, and a year later, other sections of the building were expanded to allow for respiratory therapy, nuclear medicine, pathology, and biomedical engineering, among other services.

Construction of the Tuality Health Education Center adjacent to the hospital continued expansion through 1985 and into 1986.

[5] A new birthing center was opened in May 1987 with ten single room suites for expectant mothers that were named state of the art by the American Institute of Architects.

[7] In 1988, a 20-bed Extended Care Rehabilitation Center was created within the facility, reducing the number of hospital beds to 167.

Two years later, an expanded birthing facility opened and MAX Light Rail expansion included a station at the hospital.

[14] In November 2019, Tuality Healthcare announced that it was changing the hospital's name to Hillsboro Medical Center, to better reflect its relationship with OHSU, three years after the two entities established a clinical partnership.