Hiroyuki Takei started drawing manga with writer EXIAD on SD Département Store Series which they created for a fanzine.

Early in his career, he became the assistant to Tamakichi Sakura on The Form of Happiness (しあわせのかたち, Shiawase no Katachi) as Turtle-san (カメさん, Kame-san) in 1992 and Kōji Kiriyama (Ninku).

In 2007, Takei returned three years after the conclusion of Shaman King with a new Weekly Shōnen Jump series, entitled Jumbor Barutronica.

On March 4, 2008, Japanese publisher Shūeisha announced that Takei would be collaborating on Karakuri Dôji Ultimo with American comic creator Stan Lee.

[17] In an interview with Shonen Jump, he also cited Taiyo Kosoku by Baru, Blade of the Immortal by Hiroaki Samura, and Hellboy by Mike Mignola as favorites.