[1] Hisako accompanied her father to England, where he was transferred for work, and while still a child became fluent in the English language.

On 23 April 1984, she attended a reception hosted by the Embassy of Canada in Tokyo, where she first met Prince Norihito of Mikasa, grandson of Emperor Taishō.

They have three daughters: Prince and Princess Takamado were the most widely traveled couple in the Japanese Imperial Family, visiting 35 countries together in 15 years to represent Japan on various functions.

The Prince's last visits included Egypt and Morocco in May 2000, Hawaii in July 2001 (to promote the Japanese tea ceremony), and to South Korea from May to June 2002.

Since November 2002, the princess has served as the Honorary President of the Prince Takamado Trophy, All Japan-Middle School English Oratorical Contest.

[7] In March 2004, the Princess was elected to succeed Queen Noor of Jordan as honorary president of BirdLife International.

[8] In November 2004, she visited Bangkok, Thailand, to attend the 3rd IUCN World Conference as honorary president of BirdLife International.

In January 2006, she returned to Canada to attend the opening of the "Prince Takamado Gallery of Japan" at the Royal Ontario Museum.

[10][11] In March 2020, Princess Takamado underwent surgery for acute appendicitis at the University of Tokyo Hospital.