Frogs and lizards (particularly Anolis species) are the most common prey item; however, individuals have also been recorded to prey on smooth-billed ani (Crotophaga ani), house mouse (Mus musculus) and native boas (Chilabothrus sp.).

Pursuits of juvenile rhinoceros iguanas (Cyclura cornuta) and rats (Rattus sp.)

The majority of the racer's range lies in the Dominican Republic, where it is found in the southwest of the country (in the arid areas surrounding Lake Enriquillo, Pedernales Province, and Isla Beata) as well as a relict population in Monte Cristi Province.

The Hispaniola racer is primarily found in xeric open-thorn forest, as well as transitional areas into oases and river valleys.

Agricultural expansion, deforestation for charcoal production (especially in Haiti), and predation from invasive species, such as feral cats (Felis catus) and small Indian mongooses (Urva auropunctata) are all factors that have resulted in the range and population reduction of H. anomalus.