They are positively coupled to adenylate cyclase via Gs alpha subunit.

It is a potent stimulant of cAMP production, which leads to activation of protein kinase A.

[5] PKA functions to phosphorylate certain proteins, affecting their activity.

It is an integral membrane protein and stimulates gastric acid secretion.

Activation of the H2 receptor results in the following physiological responses: This article incorporates text from the United States National Library of Medicine, which is in the public domain.