Hive appeared in the third season of the TV series Agents of S.H.I.E.L.D., where he was an ancient Inhuman and was primarily portrayed by Brett Dalton.

Grotesque and menacing in both stature and appearance, Hive had no identity of its own, per se, as its collective will dominated the human host.

[2] When HYDRA went to war against the rival organization Leviathan, Valentina revealed her true allegiance and murdered her predecessor, Viper.

[5] During this brief and fragile union, Osborn arranged for Madame HYDRA to undergo surgery to remove the Hive from her in a way that would keep her alive.

[7] During the Secret Empire storyline, Hive was shown to have taken control of the Hand when the Underground encountered him and Gorgon in Madripoor.

In this form it was capable of speech—the language, however, is unknown, though spoken also by other HYDRA agents—suggesting it was one of their own design, created for strategic secrecy when in the field.