Created by Brian Michael Bendis and Mark Bagley, she is the Ultimate Marvel equivalent of Ben Reilly and both iterations of Spider-Woman (Jessica Drew and Julia Carpenter).

In 2023, the character made their cinematic debut in the animated feature film Spider-Man: Across the Spider-Verse as a member of Miguel O'Hara's Spider-Society.

[3] Spider-Woman is a genetically engineered clone of the original Spider-Man, Peter Parker, whose chromosomes were manipulated to make her biologically female.

[5] At the storyline's close, Spider-Woman decides to start a new life apart from Peter, takes her leave of him after what she calls "the most awkward hug in history", establishing a sibling-like relationship with him.

[6] Spider-Woman later appears during the "Ultimatum" storyline, making their public debut when they help Johnny Storm apprehend the Vulture.

[7] Storm begins to develop a romantic interest in Spider-Woman after a bad date with a famed but obnoxious teen singer, unaware that she is Spider-Man's female clone.

They later meet May Parker while aiding civilians during Magneto's worldwide attack,[8] taking them to safety and promising to find Peter for them.

[9] Later, she travels to the center of Manhattan where Doctor Strange's home is being attacked by Nightmare; the Hulk begins to destroy the portal to the Dark Dimension, causing an explosion.

[15] In Ultimate Doom, Spider-Woman awakens to find herself bound on a table and meets the Brain Trust's leader, Doctor Octopus.

Rick Jones arrives with the Human Torch and they learn that heroes are gathering to take down Reed Richards.

[17] After Peter apparently dies fighting the Green Goblin, Spider-Woman confronts the new Spider-Man, Miles Morales.

During the "Spider-Verse" storyline, Spider-Woman teams up with Kaine and an alternate Ben Reilly to investigate the home of the Inheritors and find out how they are able to clone new bodies for themselves.

[31] Spider-Woman has all the powers of Spider-Man, including superhuman strength, speed, and agility, the ability to stick to surfaces and a spider-sense that warns them of danger.

After fending off Morlun in 2006 while Peter is involved in the superhero Civil War, by 2019 Claire has become Spider-Woman with the Ultimate Spider-Woman costume, remaining on Earth to protect her brother Benny and mother Mary Jane as he goes to space face Doctor Doom along with Miles Morales (actually Otto Octavius).

[35] Michael Austin of CBR.com stated, "Not only is the mainstream Jessica Drew incredibly cool, but her Ultimate universe counterpart is also an equally impressive character as well.