Holcomb is an unincorporated community and census-designated place (CDP) in Grenada County, Mississippi, United States.

The community was founded in 1901 on land that once was the home site of Choctaw Indian Chief Isaac Perry.

[5] Holcomb is in western Grenada County, on the south side of the valley of the Yalobusha River.

According to the U.S. Census Bureau, the Holcomb CDP has an area of 4.7 square miles (12.3 km2), all of it land.

[3] The climate in this area is characterized by hot, humid summers and generally mild to cool winters.