It was the result of the union of the two adjacent towns (separated by the present-day Line Street) of Pittsburg and Tulahoma (or Tullahoma), founded, respectively, by Franklin Plummer and Hiram Runnels.

[citation needed] In 1851, Grenada townspeople founded the Yalobusha Baptist Female Institute for education of their young White women.

[8] On December 20, 1862, Confederate general Earl Van Dorn, whose troops were encamped in Grenada, led the three brigades under his command in a raid that destroyed the Union supply depot at Holly Springs, Mississippi.

[11][12][13] In 1966, Martin Luther King Jr. and Dick Gregory spent a week demonstrating in Grenada against discrimination and for voters' rights.

[15] As the civil rights movement continued to press in 1966 and 1967 for voter registration and opportunities in employment, the Southern Christian Leadership Conference (SCLC) ran a civil rights organizing project in Grenada which lasted at least 11 months.

[16] They worked to register voters and gain concessions for hiring black Americans in local businesses and restaurants.

In August 1966, a federal judge ordered Grenada to allow black students to enroll in the previously all-White schools.

White leaders used threats of eviction and firing to coerce black parents to withdraw their children from school.

A group of White people met them at the school and chased them away, pursuing them through the streets and beating the children with chains, pipes and clubs.

This festival, celebrating its 30th anniversary in 2025, has a variety of events including fishing tournaments, carnival rides and fireworks displays.

Milwaukee Tool announced a major expansion in 2022, creating 800 new jobs and establishing a new facility in the area.

This expansion is part of a broader effort to bolster the local economy and provide new employment opportunities.

[29] Since 2008, Holmes Community College has partnered with the University of Mississippi (Ole Miss) to offer a range of undergraduate and graduate degree programs at the Grenada campus.