Holly Hill is a town in Orangeburg County, South Carolina, United States.

Prior to 1910 it was located in the northwest portion of Saint James Goose Creek Township.

[5] Dantzler Plantation and Providence Methodist Church are listed on the National Register of Historic Places.

[7] According to the United States Census Bureau, the town has a total area of 1.4 square miles (3.6 km2), all land.

As of the 2020 United States census, there were 1,298 people, 507 households, and 321 families residing in the town.