Edisto is an unincorporated community and census-designated place in Orangeburg County, South Carolina, United States.

[3] U.S. Route 601 passes through the community.

According to the U.S. Census Bureau, the community has an area of 5.458 square miles (14.14 km2); 5.418 square miles (14.03 km2) of its area is land, and 0.040 square miles (0.10 km2) is water.

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