Holy Angels Church is located in the lower west side of Buffalo, New York, adjacent to D'Youville College.

[1] In October 2020, D'Youville College purchased the Holy Angels Church, Rectory, and Convent.

[2][3][4] At the request of Bishop John Timon, who had recently organized the Diocese of Buffalo, missionaries from the Oblates of Mary Immaculate arrived in 1851 to establish a seminary and college at the site of today's St. Joseph Cathedral rectory on Franklin Street.

The site of the present-day Holy Angels Church was purchased in 1852, where two abandoned buildings (formerly the county poorhouse and insane asylum) were converted into a college and chapel.

In 1874 work was started on the transept, sanctuary and choir, completing the building's modern appearance a year later.