Holy Cross is a city in Dubuque County, Iowa, United States.

[3] According to the United States Census Bureau, the city has a total area of 0.34 square miles (0.88 km2), all land.

Originally the community was settled by Irish and German immigrants in the early 19th century.

This name honored George Gallon, who offered to donate part of his land to build a town.

On May 17, 2004 several buildings in town were either damaged or destroyed when major storms ripped through the area.

The church suffered serious damage when part of its roof was ripped off in the storm.

There were 159 housing units at an average density of 485.0 per square mile (187.3/km2).

There were 158 housing units at an average density of 464.7 per square mile (179.4/km2).

25.8% of all households were made up of individuals, and 8.6% had someone living alone who was 65 years of age or older.

There were 139 housing units at an average density of 488.7 per square mile (188.7/km2).

22.7% of all households were made up of individuals, and 9.1% had someone living alone who was 65 years of age or older.