Holy Cross Armenian Apostolic Church is a significant Armenian Apostolic Church in Washington Heights, Manhattan, New York City at 580 West 187th Street.

The church building was built between 1925 and 1926 at a cost of $30,000 to designs by an architect Stoyan N. Karastoyanoff of 220 Audubon Avenue.

[1] The Lutheran congregation moved into their parish house after the Great Depression, and the Armenian Apostolic Church took over the building in 1929.

[2][3] On December 24, 1933, a group of assassins attacked Eastern Diocese Archbishop Levon Tourian as he walked down the aisle of Holy Cross Armenian Church in the Washington Heights neighborhood of New York City during the Divine Liturgy, and killed him with a butcher knife.

The incident divided the Armenian community, as Tashnag sympathizers established congregations independent of Mother See of Holy Etchmiadzin, declaring loyalty instead to the Holy See of Cilicia based in Antelias, Lebanon.