Holy Cross College is an autonomous women's college located in Tiruchirappalli, Tamil Nadu, India.

It has been recognized as the 'College with Potential for Excellence (CPE)' by the University Grants Commission.

[1] The college is ranked 39th among colleges in India by the National Institutional Ranking Framework (NIRF) in 2024.

The college was conferred autonomous status in 1987 by the UGC.

[4] The college offers undergraduates and postgraduate programmes in arts and science affiliated to the Bharathidasan University.