Later, Holy Family would serve the local Catholic institutions on Queen Street (now the Queensway) that had been created in St. Helen's Parish in the 1870s during Parkdale's first period of growth as an independent village; Sacred Heart Orphanage (now St. Joseph's Health Centre) and Our Lady of Mercy Palliative Care Centre originally run by the Sisters of St. Joseph, that first opened in Toronto Architect John Howard's 'Sunnyside' home, as well as Our Lady of Charity convent and school for wayward girls (now demolished) that was opened out of Parkdale founder Captain O'Hara's 'West Lodge' home by the Good Shepherd Sisters.

Shortly after, in 1914, St. Vincent de Paul parish was created to serve the growing Howard Park (Roncesvalles) neighbourhood to the north of Parkdale.

Coyle, Monsignor Brennan (Rector of St. Augustine's Seminary) was appointed pastor; he led the parish during a time of liturgical reforms in the Latin Rite.

In the post war years Parkdale lost much of its affluence while it redeveloped as a high-density immigrant reception neighbourhood, leading to an exodus of many older residents and the closure of many Protestant churches because of declining membership.

[5] In 1995 the Oratorians at Holy Family were given the additional care for the declining St Vincent de Paul parish to which some of them moved for a time.