Homer Estell Ezzell (February 28, 1896 – August 3, 1976) was a third baseman in Major League Baseball who played from 1923 through 1925 for the St. Louis Browns (1923) and Boston Red Sox (1924–25).

Listed at 5 ft 10 in (1.78 m), 158 lb., Ezzell batted and threw right-handed.

In a three-season career, Ezzell was a .264 hitter (196-for-236) with 61 RBI in 236 games played, including 106 runs, 20 doubles, eight triples and 25 stolen bases.

Ezzell died in San Antonio, Texas at age 80.

This biographical article relating to an American baseball third baseman is a stub.