Part of the Mequon-Thiensville School District, it serves a 48-square-mile (120 km2) area including the city of Mequon and the village of Thiensville.

The area on which Homestead High School now stands originally belonged to the Potawatomi and Menominee Indians.

Originally the school consisted of four wings, two music rooms, a small theater, cafeteria, and a gymnasium.

Three additional wings, the library, a swimming area, another gymnasium, a lecture hall, and an auditorium were added in 1968.

Artists can select from courses in acting, directing, technical theatre, concert band, string orchestra, Highlander Choir, metals, ceramics, digital art, painting, photography, AP Music Theory, AP Research, and other stuff.