Although Nurse with Wound had generated considerable interest across their preceding releases, Steven Stapleton has asserted to author David Keenan that Homotopy to Marie should be considered the first "real" NWW album.

It is, as Keenan notes, audibly less musically conventional than its predecessors and relies on Stapleton's improving abilities of tape-editing and construction, honed during these Friday evening sessions.

A compact disc edition was released in 1992 with alternate artwork (pictured) and an additional contemporaneous recording, "Astral Dustbin Dirge", which had been omitted from the original formats for reasons of length.

The album went out of print when distributor World Serpent went out of business but was reissued on United Dairies in June 2007 in remastered form, with the correct index points and the original track titles restored.

The laughter heard on "The Tumultuous Upsurge (Of Lasting Hatred)" is sampled from the King Crimson song "Easy Money" from the album Larks' Tongues in Aspic.