Originally intended primarily for the Thai and Indian markets, the 250R was sold worldwide, including in developed countries in Europe, North America and elsewhere.

[8][2][9] In developing countries where typical motorcycles are 125–150 cc (7.6–9.2 cu in) displacement, the larger 249.5 cc (15.23 cu in) CBR250R is at the higher end of the sport bike range,[10] looking similar to much more powerful sporting machines with its full fairing in Honda's new layered style that was introduced on the 2008 CBR1000RR Fireblade and 2010 VFR1200F.

[7][11] In wealthier industrialized countries, the CBR250R enters at the opposite end of the market, as a budget priced beginner or utility bike, practical and fuel efficient, but with limited sporting pretensions.

The CBR250R closely follows the style of the VFR1200F, notable for its Y-shaped headlight and prominent middle cowl, which creates a layered look.

[15] Kerr cites the Chrysler 300 as the best example, as well as smaller cars like the Audi A3 and Suzuki Swift, commenting that, "aggression now comes from appearing strong and assertive, rather than light and dart-like... the arrow has been replaced by the hammer.

[4][17] Complaints from The Economic Times of Mumbai included a tendency to stand up if the rider makes a sloppy mid-corner correction, and brakes and suspension not up to the standards of a track bike.

[4] Kevin Ash, at 6 ft 3 in (1.91 m), found the dimensions comfortable for someone of his height, while David Booth cautioned it could be cramped for taller riders.

[21] Global models of the CBR250R were produced by Thai Honda Manufacturing in Thailand, with sales beginning in November 2010, followed by spring 2011 in Japan.

[10] In October 2013 the longer-stroke CBR300R was announced at the China International Motorcycle Trade Exhibition in Chongqing, with engine displacement increased from 249.6 to 286 cc (15.23 to 17.45 cu in) in response to Kawasaki's Ninja 300.

Further external changes include a new exhaust system and revised motor mounts, a new seat and side panels that aid in an easier reach to the ground and a slightly more sporty riding position.

Internal changes include new piston, connecting rod and crankshaft along with increase in displacement and taller gearing for better cruising.

[36] It has LED lighting with hazard button, battery voltmeter, dual-channel ABS, a switchable traction control system and a USB charger.