Styled by Honda Design Studio in Los Angeles, the Prologue is based on the Ultium architecture and the BEV3 platform developed by General Motors, which it shares with the Chevrolet Blazer EV, Acura ZDX, and Cadillac Lyriq.

According to Hwang, the frame rails, the floor, the front and rear suspension subframes, pedal box, steering column mounting, the base of the windshield, and firewall are shared with the Blazer EV.

Honda designers and engineer are given freedom to develop its own sheetmetal, and tuned the steering calibration, springs and dampers independently from the Blazer EV.

[5] While having a unique interior design, the Prologue shares many components with the Blazer EV, including the steering wheel and stalks, climate settings controls, door handles and locks, and window switches.

The drive mode shifter is column mounted, allowing for more space in the center console, which features two side-by-side cupholders behind a flat storage tray, and a pocket style vertical wireless phone charger.