On Masanaga's death in 1634, Tadaoki inherited Iwakitaira Domain and turned his 20,000 koku holding over to his brother, Naitō Masaharu, who received official confirmation as a daimyō.

His son, Itakura Katsukiyo served as rōjū and traded places with Honda Tadayuki of Sagara Domain in 1746.

The Honda clan continued to rule Izumi domain through the remainder of the Edo period.

Honda Tadatoshi served as jisha-bugyō and led the domain in support of the Tokugawa during the Boshin War.

Following the Meiji restoration, he was punished for his support of the Ōuetsu Reppan Dōmei by a reduction in income of 2000 koku, and was forced to resign in favor of his adopted son Honda Tadanobu, who served as imperial governor until the abolition of the han system in 1871.

In 1746, the Tokugawa shogunate relocated the clan to Izumi Domain in southern Mutsu Province.

he is noted for establishing grain stores in each village as insurance against famine, and for banning abortion in his domain.

He was instrumental to the shogunate's Kansei Reforms and also strongly pushed for increasing Japan's defences against the southward expansion of the Russian Empire, which threatened Ezo.

He was posthumously adopted on the death of his older brother, Honda Tadanori in 1860, and was received in formal audience by Shōgun Tokugawa Ieshige.

In 1868, with the start of the Boshin War, he favored the imperial cause, but was pressured into joining the pro-Tokugawa Ōuetsu Reppan Dōmei instead.

As a result, the domain was invaded by the forces of the Satchō Alliance and Izumi jin’ya was burned during the Battle of Iwaki.

Honda Tadanobu (本多忠伸, February 11, 1852 – March 5, 1903) was the 7th and final daimyō of Izumi Domain.

As his predecessor, Honda Tadatoshi had been forced into retirement by the Meiji government over his involvement in the Boshin War.