The company has a flagship restaurant on Powell Boulevard, in southeast Portland's Creston-Kenilworth neighborhood, and additional pubs at Portland International Airport and in Vancouver, Washington.

Previously, there was an additional restaurant on North Williams Avenue.

[1] Hopworks was founded by spouses Christian and Brandie Ettinger in 2007.

[2][3] The Portland International Airport restaurant opened in 2019.

[4][5] In 2020, during the COVID-19 pandemic in Oregon, Hopworks' pub on North Williams Avenue closed.