Witherstine (April 2, 1852 – October 2, 1924) was an American physician and politician.
Born in Herkimer, New York, he attended Fairfield Academy, then moved to Rochester, Minnesota in 1872 where he was a school teacher.
In 1884, he received his medical degree from Rush Medical College and returned to Rochester to practice medicine.
From 1903–1910, he served in the Minnesota State Senate as a Democrat.
He died in an auto accident two miles north of Rochester while on a house call.