Known as Horace Harding Boulevard, NY 25D went east through western Queens, crossing through the Rego Park section of the city.

East of Rego Park, the route crossed an interchange with exit 8 of the Grand Central Parkway.

The route, named after financier J. Horace Harding, crossed through Flushing Meadows Park, paralleling to the north of NY 25 and the Grand Central Parkway.

The route crosses through the southern end of Douglaston, running northeast to the Nassau County.

Paralleling the Northern State Parkway, the route ran northeast along local streets, crossing through the North Hills section of the county.