He was a professor of zoölogy at the University of Pennsylvania from 1894 to 1905, secretary of Penn's biological faculty (1884–1889), and dean of Penn's college faculty (1889–1894).
He became a trustee of Drexel Institute, and served as co-editor of several scientific journals.
[3] He married ethnologist Caroline Furness Jayne (1873–1909), and they had two children.
Their son, Horace H. F. Jayne (1898–1975), became the first curator of Chinese art at the Philadelphia Museum of Art, and later was director of the University of Pennsylvania Museum of Archaeology and Anthropology, and vice director of the Metropolitan Museum of Art.
He died on July 19, 1913,[1] and was interred at Laurel Hill Cemetery in Philadelphia.