Horcajo Medianero is a village and municipality in the province of Salamanca, western Spain, part of the autonomous community of Castile-Leon.

It is located 48 kilometres (30 mi) from the provincial capital city of Salamanca and has a population of 329 people.

The municipality covers an area of 53 km2 (20 sq mi).

It lies 1,008 metres (3,307 ft) above sea level and the postal code is 37860.

This article about a location in the province of Salamanca, Spain, is a stub.