The Horseracing Integrity and Safety Authority (HISA) is a private self-regulatory organization that regulates the sport of Thoroughbred horse racing in the United States.

[19] It regulates matters such as track surface maintenance, veterinary oversight, injury data reporting, jockey safety, horseshoe requirements, and use of riding crops.

[24][25] Administration of the rules, including collecting and testing of blood, urine, and hair samples, is delegated to the Horseracing Integrity & Welfare Unit, a subsidiary of Drug Free Sport International, a private drug-testing company.

[28] In addition to Texas, racing jurisdictions in Louisiana and West Virginia continue to operate under state rules as of the implementation of the HISA while awaiting the resolution of legal challenges.

[28] In September 2023 Republican congressman Clay Higgins of Louisiana introduced a bill that would replace the HISA with a new agency.