Hoshina Masatsune (保科 正経, February 1, 1647 – November 12, 1681) was the 2nd daimyō of Aizu Domain in Mutsu Province, Japan (modern-day Fukushima Prefecture).

Masatsune was the fourth son of Hoshina Masayuki and became daimyō in 1669 on the retirement of his father.

He understood the construction of his father's monumental grave at Hanitsu Jinja in Inawashiro in 1675.

He is also known for reviving the Oyaku-en, a medicinal herbs garden which had been established by the Ashina clan during their tenure over Aizu.

However, his tenure was a constant struggle against the machinations of his mother, Shoko-in (1620-1691), who wielded a strong influence and promoted less-than-qualified relatives to various high posts, including that of karō.