The hospital was founded in 1925 in by Dr. Manuel de la Pila Iglesias, a Spaniard from Cádiz, Spain, who had been raised in Ponce.

[3] The hospital was founded as a small medical clinic; it has since grown considerably.

It was originally named "Clinica Quirurgica del Dr. de la Pila Iglesias" (Surgical Clinic of Dr. de la Pila Iglesias).

[4] Between 1980 and 1983, the Ponce Municipal Government, seeking to relocate Hospital Tricoche to a more accessible and spacious quarters, built new facilities on Avenida Las Americas (PR-163).

[9] Metro Pavia started operating Hospital Dr. Pila in early 2010.