It was founded in 1946[5][6] by Asociacion Lucha Contra el Cancer.

[7] In 1962 the hospital was established on the grounds of then Centro Medico de Ponce (a.k.a.

In 2010, the Legislature of Puerto Rico transferred the lands occupied by Hospital Oncológico Andrés Grillasca Salas to the hospital's corporation free of cost.

In 2012, after falling on hard financial times, the hospital received financial assistance from the Government of Puerto Rico which kept it operating.

[11][12] In 2010, the hospital had 28 physicians, 20 nurses, and 50 support personnel.