In 1993, he graduated from the Andijan State Pedagogical Institute with a degree in Russian language and literature.
From 2004 to 2013, Ketmenov served as Deputy Hokim of Andijan region for public relations and religious organizations.
From 2013 to 2019, Ketmonov was the chairman of the Central Council of the People's Democratic Party of Uzbekistan (PDPU).
From January 2015, he was the parliamentary leader of the PDPU faction and the Deputy Speaker of the Legislative Chamber of the Oliy Majlis.
[2] On 17 September 2016, the Central Council of the PDPU nominated Ketmenov as a candidate in the 2016 snap presidential election which was held after the death of President Islam Karimov.