The Hotel Café is a live music venue located off an alley on the Cahuenga Boulevard strip in Hollywood, California, United States, that has become known for helping to establish the careers of new singer-songwriters in the 2000s.

The venue began as a coffee shop, but has gained a reputation as an intimate performance space featuring acoustic-based songwriters.

Co-owner Maximillian Mamikunian has noted that in the venue's early days, turning a profit was challenging, as the cafe's steamers and blenders could only be run between songs so as not to drown them out.

The Hotel Café's website, like the venue itself, has served as a source for new artists to be tapped by music enthusiasts and industry professionals alike.

Grey's Anatomy music supervisor Alexandra Patsavas has used both the website and club itself as sources for discovering artists and songs she uses on the show.