It was directed by George Archainbaud[1] and stars Leo Carrillo, Lynne Overman, Spring Byington, Benny Baker and Colette Lyons.

Dentist Henry Parkhouse (Lynne Overman) and his wife Minerva (Spring Byington) have a perfect marriage until a practical joke backfires and she finds a lady's chemise in his coat pocket.

Wife and husband both consult Dr. Zodiac Z. Zippe (Leo Carrillo) about what to do, and vaudevillians-turned-detectives Bertie and Genevieve Sterns (Benny Baker and Collette Lyons) get involved as well.

[4] Franklin Pangborn, who would go on to be one of the character actors frequently used by Preston Sturges in the movies he wrote and directed, has a small uncredited part as a Fuller Brush Man.

[5] Preston Sturges was paid $17,500 by Paramount to write Hotel Haywire for Charlie Ruggles, Mary Boland, George Burns and Gracie Allen.